Neuropsychiatric syndromes in Alzheimer’s disease: Systematic review and meta‐analysis of the factor structure of the neuropsychiatric inventory

Background Neuropsychiatric symptoms (NPS) are a prevalent feature in patients with Alzheimer’s disease (AD). Studies have consistently observed that certain NPS tendency to co-occur others. One major focus of research has been understand the factor structure Inventory (NPI) identify neuropsychiatric syndromes AD. Whilst there is large literature studies, exists heterogeneity results derived. Method We sought increase our certainty about how AD may be defined by conducting systematic review and meta-analysis from 1994-2020 regarding NPI. used meta-analytic structural equation modelling (MASEM) pool effect sizes (correlation coefficients between NPI items) under random effects model fitted measurement models published studies best-fitting structure. Result Twenty-four met eligibility criteria however were only available for seven studies. For NPI-10 (7 n = 5185), five-factor was found good fit data across majority indices (CFI 0.966; TLI 0.940; SRMR 0.031; RMSEA 0.026 [95% CI 0.021, 0.030]). NPI-12 (4 2397), we unable displayed fit. Conclusion Our indicated – agitation, irritability, aberrant motor behaviour (factor 1); delusions hallucinations 2); depression anxiety 3); euphoria disinhibition 4); apathy 5) model.